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Handbook of Extemporaneous Preparation

A Guide to Pharmaceutical Compounding

First edition

Edited by Mark Jackson - Quality Control and Quality Assurance Manager at Leeds Teaching Hospitals, UK and Andrew Lowey - Clinical Pharmacy Manager at Leeds Teaching Hospitals, UK

Handbook of Extemporaneous Preparation is a comprehensive and easy-to-follow guide to good practice in extemporaneous compounding.

Written by experts in the field with input from the UK NHS Pharmaceutical Quality Assurance Committee, this book is an invaluable reference for any clinical or procurement pharmacist, pharmacy technician or student involved with extemporaneous preparation.

Written in two parts, this book provides:

  • standards for extemporaneous dispensing
  • stability summaries for the 50 most commonly prepared extemporaneously prepared medicines in NHS hospitals.

It also includes sections relating to clinical risk assessment and advice for procuring "Specials" from manufacturers.

It incorporates the key findings and outputs from the UK National Advisory Board study, including advice on purchasing unlicensed medicines. Although the standards set out in this book are primarily written for implementation in NHS hospitals, the principles should be equally applied across the profession internationally.

Handbook of Extemporaneous Preparation is also available as an eBook.

Part A - Standards
1. Introduction
2. Risk Management
3. Quality Management
4. Personnel & Training
5. Premises & Equipment
6. Documentation
7. Preparation
8. Formulation & Stability
9. Quality Control
10. Complaints, Product Recalls & Adverse Events
11. Procurement & Quality Assessment of Extemporaneously Prepared Medicines
12. Audit & Monitoring

Part B - Extemporaneous Preparation Formulary
13. Introduction
14. Formulary of Extemporaneous Preparations:

Acetazolamide oral liquid
Allopurinol oral liquid
Amiodarone hydrochloride oral liquid
L-Arginine hydrochloride oral liquid
Azathioprine oral liquid
Bendroflumethiazide oral liquid
Captopril oral liquid
Clobazam oral liquid
Clonazepam oral liquid
Clonidine hydrochloride oral liquid
Clozpine oral liquid
Co-careldopa oral liquid (levodopa and carbidopa)
Co-enzyme Q10 oral liquid
Dexamethasone oral liquid and dexamethasone sodium phosphate oral liquid
Diazoxide oral liquid
Dinoprostone (prostaglandin E2) oral liquid
Ergocalciferol oral liquid
Ethambutol hydrochloride oral liquid
Gabapentin oral liquid
Gliclazide oral liquid
Hydrocortisone oral liquid
Indometacin (indomethacin) oral liquid
Isosorbide mononitrate oral liquid
Joulie's solution (oral phosphate supplement)
Knox mouthwash
Levothyroxine sodium oral liquid
Lorazepam oral liquid
Magnesium glycerophosphate oral liquid
Menadiol sodium phosphate oral liquid
Metformin hydrochloride oral liquid
Midazolam hydrochloride oral liquid
Morphine sulfate oral liquid
Omeprazole oral liquid
Phenobarbital and phenobarbital sodium oral liquid
Phenoxybenzamine hydrochloride oral liquid
Potassium acid phosphate oral liquid
Primidone oral liquid
Pyrazinamide oral liquid
Pyridoxine hydrochloride (vitamin B6) oral liquid
Quinine sulfate oral liquid
Sildenafil citrate oral liquid
Sodium bicarbonate oral liquid
Sodium chloride oral liquid
Sodium phenylbutyrate oral liquid
St Mark's solution
Tacrolimus oral mouthwash
Tacrolimus oral suspension
Thiamine hydrochloride oral liquid
Tranexamic acid oral mouthwash
Vancomycin hydrochloride oral liquid
Warfarin sodium oral liquid

Appendix 1: Change control request form

Appendix 2: Deviation reporting form

Appendix 3: Example raw material specification

Appendix 4: Example worksheet

Appendix 5: Technical agreement for commissioning of extemporaneous product preparation service

Appendix 6: Audit tool for extemporaneous preparation

Appendix 7: Suspending agents

Adobe PDF Sample chapter (184 KB)

Oct-2011, Australian Prescriber

"...this resource offers a real advantage to both the prescriber and the pharmacist in the provision of quality oral liquids...Of particular use and unique to this text is the inclusion of a 'risk assessment' section in each monograph which addresses the clinical and technical risks associated with the extemporaneous preparation of each oral liquid...This book is not only a useful resource, but a valuable addition to the texts available on extemporaneous dispensing for those prescribers wanting quick access to suitable oral liquid alternatives..."

Alison Haywood, Senior Lecturer, Griffith University, and Beverley Glass, Professor of Pharmacy, James Cook University Queensland, Australian Prescriber 34(5), October 2011.

 
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ISBN 978 0 85369 901 9

Published May 2010

Paperback
234 x 156mm (480pp)