Jambhekar, Sunil S; Breen, Philip J
Sunil S Jambhekar - Professor of Pharmaceutics, LECOM-Bradenton School of Pharmacy, Florida, USA and Philip J Breen - Associate Professor of Pharmaceutics, School of Pharmacy, University of Arkansas Medical Center, USA
Basic Pharmacokinetics provides an understanding of the principles of pharmacokinetics and biopharmaceutics. It addresses clearly and concisely how these principles can be applied to achieve successful drug therapy. The applications of principles and equations are illustrated with related problem sets and problem solving exercises.
- the use of profiles (sketches of relationships among pharmacokinetic variables and parameters)
- learning objectives
- complete review of mathematical tools required to practice pharmacokinetics.
This new edition has been revised and updated to include:
- new chapters on metabolite pharmacokinetics and pharmacokinetic data fitting
- expanded question data base to include multiple choice questions and true/false questions
- a large increase in the number of questions based on pharmacokinetic profiles.
Basic Pharmacokinetics is an invaluable textbook for undergraduate and graduate students in pharmacy, medicine, and the pharmaceutical sciences. It enables the reader to become adept at solving pharmacokinetic problems arising in drug therapy and to understand the applications and utility of equations in clinical practice.
Basic Pharmacokinetics is also available as an eBook.
1. Introduction and Overview
2. Mathematical Review
3. Intravenous Bolus Administration (One-compartment Model)
4. Clearance Concepts
Problem Set 1
5. Drug Absorption From the Gastrointestinal Tract
6. Extravascular Routes of Drug Administration
Problem Set 2
Problem Set 3
8. Factors Affecting Drug Absorption: Physicochemical Factors
9. Gastrointestinal Absorption: Role of the Dosage Form
10. Continuous Intravenous Infusion (One-compartment Model)
Problem Set 4
11. Multiple Dosing: Intravenous Bolus Administration
12. Multiple Dosing: Extravascular Routes of Drug Administration
Problem Set 5
13. Two-compartment Model
Problem Set 6
14. Multiple Intermittent Infusions
Problem Set 7
15. Nonlinear Pharmacokinetics
Problem Set 8
16. Drug Interactions
Problem Set 9
17. Pharmacokinetic and Pharmacodynamic Relationships
Problem Set 10
18. Metabolite Pharmacokinetics
19. Pharmacokinetic Data Fitting
20. Pharmacokinetics and Pharmacodynamics of Biotechnology Drugs
Appendix: Statistical Moment Theory in Pharmacokinetics
From the reviews of the previous edition:
'Although directed at entry-level PharmD students, the book also may be useful for medical students, graduates, and pharmaceutical scientists with a lack of pharmacokinetic education...the authors appear to be experts in the field of pharmacokinetics with experience teaching the subject in a pharmacy curriculum...the authors have done a great job of explaining basic pharmacokinetic principles and mathematical equations.'
Jamila Stanton, PharmD, BCPS, Doody's Notes, 14th August 2009
'It explains the basics in a clear way which is appropriate for MPharm undergraduates, however still covers the more advanced areas in a way suitable for practitioners or postgraduate users. This would be ideal for MPharm students who normally study the two subjects at the same time.'
Michael Taylor, Lecturer in Pharmaceutics, School of Pharmacy and Pharmaceutical Sciences, University of Central Lancashire, UK, January 2010