Molecular Biopharmaceutics
Aspects of Drug Characterisation, Drug Delivery and Dosage Form Evaluation
First edition
Edited by Bente Steffansen - Associate Professor, Birger Brodin - Associate Professor and Carsten Uhd Nielsen - Associate Professor
Covers a complex and developing academic scientific area, comprehensively encapsulating the essentials of the topic. The book's focus is on describing the interplay between the chemistry of drug molecules and membrane transporters.
It also aims to guide researchers in setting up experiments that may help in understanding the mechanisms and kinetics involved in drug absorption, transport and delivery.
Starting with an introduction to the topic, Molecular Biopharmaceutics then considers the following:- physico-chemical characterization of drug candidates
- membrane transport of drug candidates
- describing and predicting bioavailability
This topic is of increasing importance in drug development. This book will be an invaluable resource for postgraduate pharmaceutical science students, biopharmaceutical scholars, scientist within academia and pharmaceutical scientists.
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Reviews:
04-Dec-09, IJPC:
'Some specific chapters of interest include Mechanisms of Decomposition of Drug Candidates, Kinetics of Decomposition in Aqueous Solution, Structure and Function of Absorption Barriers, Passive Diffusion of Drug Substances: The Concepts of Flux and Permeability, and The Biopharmaceutics Classification System in Drug Discovery and Development. These topics should be of interest to advanced compounding pharmacists that wish to "dig deeper" into formulation development and possibly prepare better for the future in compounding.'
The International Journal of Pharmaceutical Compounding, Volume 6, Issue 48, 4th December 2009
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Contents:
Part 1 Introduction to Molecular Biopharmaceutics: Part 2 Drug Characterization and Preformulation: 1. Pka, Solubility, Liphophilicity and Solid State Characterization of Drug Candidates: 2. Stability of Drug Candidates in Aqueous Solutions: 3. Kinetics of Acid, Base and Enzyme Catalyzed Hydrolysis: 4. Chemical Approaches to Improve Drug Delivery and Formulation of Drug Candidates: 5. Preformulation: Part 3 Drug Delivery Across Biological Membranes: 6. Biological Membrane Structures: 7. Diffusional Permeation of Drug Candidates: 8. Carrier Mediated Transport Kinetics: 9. Classification of Human Membrane Transporters: 10. Absorptive Transporters: 11. Efflux Transporters: 12. Preclinical Evaluation of Drug Transport: Part 4 Dosage Form Evaluation: 13. In Vitro Drug Dissolution: 14. Biopharmaceutical Classification System: 15. Biosimulation Studies: Part 5 Conclusions and Future Perspectives:
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$220.00
ISBN: 978 0 85369 722 0
Publication Date:
November 2009
Hardback
234 x 156mm
392pp
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