Basic Pharmacokinetics

Basic Pharmacokinetics
First edition
Sunil S Jambhekar - Professor of Pharmaceutics, LECOM-Bradenton School of Pharmacy, Florida, USA and Philip J Breen - Associate Professor of Pharmaceutics, School of Pharmacy, University of Arkansas Medical Center, USA

Enables the reader to become adept at solving pharmacokinetic problems arising in drug therapy and to understand the applications and utility of equations in clinical practice.

It is an invaluable textbook for undergraduate and graduate students in pharmacy, medicine and pharmaceutical sciences.

Basic Pharmacokinetics provides an understanding of the principles of pharmacokinetics and biopharmaceutics and of how these principles can be applied to achieve successful drug therapy. The application of principles and equations are illustrated by relevant data and chapters conclude with related problem sets and problem solving exercises.

Novel features of this text include:

the use of profiles (sketches of relationships among pharmacokinetic variables and parameters) to help the reader understand pharmacokinetics intuitively
a set of learning objectives provided at the beginning of each chapter
a complete review of mathematical tools required to practice pharmacokinetics
chapters linking dosage form design and physicochemical properties of drugs to pharmacokinetics
intuitive and physiological approaches to understanding clearance
a table of rules for converting between oral, intravenous, loading, and maintenance dosing regimens
a 3-dimensional representation of pharmacokinetics/pharmacodynamics (PKPD)
a chapter including an extensive list of cytochrome P 450 and transporter- mediated drug interactions
a chapter outlining the pharmacokinetics of the latest biotechnology drugs.

Reviews:
14-Aug-09, Doody's Notes:
'Although directed at entry-level PharmD students, the book also may be useful for medical students, graduates, and pharmaceutical scientists with a lack of pharmacokinetic education...the authors appear to be experts in the field of pharmacokinetics with experience teaching the subject in a pharmacy curriculum...the authors have done a great job of explaining basic pharmacokinetic principles and mathematical equations.'
Jamila Stanton, PharmD, BCPS, Doody's Notes, 14th August 2009

31-Jan-10, Quote From a Lecturer:
'It explains the basics in a clear way which is appropriate for MPharm undergraduates, however still covers the more advanced areas in a way suitable for practitioners or postgraduate users. This would be ideal for MPharm students who normally study the two subjects at the same time.'
Michael Taylor, Lecturer in Pharmaceutics, School of Pharmacy and Pharmaceutical Sciences, University of Central Lancashire, UK, January 2010

Contents:
1. Overview: 2. Mathematical Review: 3. Intravenous Bolus Administration: 4. Clearance Concepts: 5. Drug Absorption From the Gastrointestinal Tract: 6. Extravascular Routes of Drug Administration: 7. Bioavailability/bioequivalence: 8. Factors Affecting Drug Absorption: 9. Gastrointestinal Absorption: 10. Continuous Intravenous Infusion: 11. Multiple Dosing: Intravenous Bolus Administration: 12. Multiple Dosing: Extravascular Routes of Drug Administration: 13. Two-compartment Model: 14. Multiple Intermittent Infusions: 15. Non Linear Pharmacokinetics: 16. Drug Interactions: 17. Pharmacokinetic and Pharmacodynamic Relationships: 18. Pharmacokinetics and Pharmacodynamics of Biotechnology: Appendix: