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September 2019

Welcome to the September BNF Newsletter.

• One new drug monograph has been added to both BNF and BNFC in the last month: cefoxitin.
• One new drug monograph has been added to the BNF in the last month: chlormethine.
• We have included a dose change for typhoid vaccine to both the BNF and BNFC.
• We have also included MHRA advice on febuxostat (Adenuric®), rivaroxaban (Xarelto®), and tocilizumab (RoActemra®).

Kind regards,
BNF Team

Other topics:

Significant changes   |   Drug safety update  |   BNF 70 years  |   BNF offline   |   Feedback

Significant changes

BNF BNF only

New monograph: Renoxitin® [cefoxitin] for complicated urinary tract infections and pyelonephritis.

New monograph: Ledaga® gel [chlormethine] for mycosis fungoides (initiated by a specialist).

New preparation: Imvaggis® [estriol] for vaginal atrophy in postmenopausal women.

Blinatumomab for treating acute lymphoblastic leukaemia in remission with minimal residual disease activity [NICE guidance].

Febuxostat (Adenuric®): increased risk of cardiovascular death and all-cause mortality in clinical trial in patients with a history of major cardiovascular disease [MHRA/CHM advice].

Fluocinolone acetonide intravitreal implant for treating recurrent non-infectious uveitis [NICE guidance].

Letermovir for preventing cytomegalovirus disease after a stem cell transplant [NICE guidance].

Migraine: updated guidance on management.

Rivaroxaban (Xarelto®): reminder that 15 mg and 20 mg tablets should be taken with food [MHRA/CHM advice].

Stroke: updated guidance on management.

BNF for Children BNFC Only

New monograph: Renoxitin® [cefoxitin] for complicated urinary tract infections and pyelonephritis.

BNF BNF for Children Both BNF and BNFC

Nusinersen for treating spinal muscular atrophy [NICE guidance].

Tocilizumab (RoActemra®): rare risk of serious liver injury including cases requiring transplantation [MHRA/CHM advice].

Typhoid vaccine: updated guidance in-line with Public Health England recommendations.

Urinary-tract infections: updated guidance on management.

Dose Changes for both BNF and BNFC
Typhoid vaccine: booster dose added.

Drug Safety Update

Drug Safety Update is a monthly newsletter from the MHRA and Commission on Human Medicine. Please follow this link to review the latest Drug Safety Update.

Carfilzomab (Kyprolis): reminder of risk of potentially fatal cardiac events.

Daratumumab (Darzalex): risk of reactivation of hepatitis B virus.

Naltrexone/bupropion (Mysimba): risk of adverse reactions that could affect ability to drive.


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Celebrating 70 years of the BNF
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