Applications of LC-MS in Toxicology

Applications of LC-MS in Toxicology gives practical hands-on information on applications of LC-MS on different groups of drugs and poisons, and in different contexts.

This book covers all essential theoretical aspects of liquid chromatography coupled with mass spectrometry including:

• technical details of the instrumentation
• method development
• optimisation and validation
• quantification
• maintenance
• troubleshooting.

Further chapters cover in detail the application of LC-MS in areas such as

• systematic toxicological analysis
• drugs of abuse
• therapeutic drug monitoring
• doping in sport
• pesticides
• peptides
• further potential forensic applications.

Following the developments of LC-MS in the last decade and its establishment as the method of choice in the pharmaceutical industry, the technique is increasingly being used in other scientific disciplines, including analytical toxicology.

This authoritative text is essential reading for all forensic and clinical toxicologists and will also be useful to pharmaceutical analysis as well as analytical chemists.

1. Ionisation, Ion Separation and Ion Detection in LC-MS
2. Method Development and Optimisation of LC-MS
3. Quantification Using LC-MS
4. Method Validation Using LC-MS
5. Identification and Confirmation Criteria for LC-MS
6. Systematic Toxicological Analysis with LC-MS
7. Analysis of Therapeutic Drugs with LC-MS
8. LC-MS of Drugs of Abuse and Related Compounds
9. LC-MS in Doping Control
10. Pesticide Analysis Using LC-MS
11. LC-MS in Forensic Chemistry

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01-Dec-07, Australian Journal of Forensic Sciences:
'...a timely and authoritive text...each chapter is comprehensively referenced allowing readers to refer to peer reviewed and other publications relevant to the subject area. The book should be well received by the chromatographers and others interested in the current applications of LC-MS and its relative advantages and disadvantages with other techniques.'
Australian Journal of Forensic Sciences, 38:111-112, 2006

03-Mar-07, Bulletin of the International Association of Forensic Toxicologists:
'...arrives at a perfect time for both novice and experienced users of this instrumental technique...serves as an incredibly valuable reference. It is a well-rounded textbook that does a very nice job of addressing every important aspect of LC-MS for the analytical toxicologist. It is simply one of the very best books on the subject of LC-MS that is presently available.'
Bulletin of the International Association of Forensic Toxicologists, 37:10, 2007

01-Jan-07, Annals of Pharmacotherapy:
'A highly organized text, with chapter development and topic sections written in a manner that allows for clear understanding of materials presented...a recommended purchase for faculty and graduate students in analytical toxicology as well as for practicing specialists in the areas of analytical, clinical, or forensic toxicology.'
Annals of Pharmacotherapy, January 2007, Volume 41, p164